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KMID : 1134820120410111521
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 11 p.1521 ~ p.1527
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Immune Enhancing Effect of Medicinal Herb Extracts on a RAW 264.7 Macrophage Cell Line
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Yu A-Reum
Park Ho-Young
Choi In-Wook
Park Yong-Kon
Hong Hee-Do
Choi Hee-Don
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Abstract
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Medicinal herbs have long been used as a remedy for diverse diseases in Asia owing to their various pharmacological effect. In this study, the immuno-enhancing activity of medicinal herbs was investigated using macrophage cell lines. Specifically, we examined the effects of extracts of twelve medicinal herbs on nitric oxide (NO) production in RAW 264.7 cells, and selected five that were highly effective (Glycyrrhiza glabra, Rehmannia glutinosa, Angelica gigas, Platycodon grandflorum, and Actinidia polygama) for further immune related studies. The effects of extracts from five theses medicinal herbs, which were mainly composed of polysaccharides and proteins on the production of immune-related cytokines in the RAW 264.7 macrophage cell line and the Molt-4 T cell line were investigated. The extracts of all investigated medicinal herbs increased the production of NO and cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), interleukin-6 (IL-6) and interleukin-10 (IL-10). Additionally, they slightly increased the proliferation of T-cells when compared to the control. Overall, the result of this study suggests that the five medicinal herb extracts investigated herein are useful natural immune enhancing agents.
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KEYWORD
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medicinal herb, immunity, RAW 264.7 cell, nitric oxide, cytokine
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